I have two XLR Male to 1/4 inch TRS Male coming out of Mics three and four of the Presonus and routing back around back into the main outs of the Presonus. This is supposed to make the loop so the Skype call can record separately.
I'm connecting Audition to the Presonus simply by selecting Mic three for the guests track and Mic one for mine. It's picking up both fine, it's just picking me up on both tracks. The Skype signal is coming into Audition via the Presonus mixer.
All Audition, Skype and Mac audio settings are set entirely to Presonus.