For Responsive Web Designs (RWD), you can do it manually with CSS Media Queries. David wrote a detailed tutorial below.
Introduction to CSS Media Queries
http://www.adobe.com/devnet/dreamweaver/articles/introducing-media-queries.html
Or you can jump start your RWD projects with one of these popular Frameworks.
Foundation Zurb
http://foundation.zurb.com/templates.php
Skeleton Boilerplate
Initializr (HTML5 Boilerplate, Responsive or Bootstrap)
DMX Zone's Bootstrap FREE extension for DW
http://www.dmxzone.com/go/21759/dmxzone-bootstrap/
Nancy O.